53BP1 Polyclonal Antibody
RD83484A
ApplicationsImmunoFluorescence, Western Blot, ImmunoHistoChemistry
Product group Antibodies
ReactivityHuman, Mouse, Rat
TargetTP53BP1
Overview
- SupplierReddot Biotech
- Product Name53BP1 Polyclonal Antibody
- Delivery Days Customer5
- ApplicationsImmunoFluorescence, Western Blot, ImmunoHistoChemistry
- CertificationResearch Use Only
- Concentration1 mg/ml
- ConjugateUnconjugated
- Gene ID7158
- Target nameTP53BP1
- Target descriptiontumor protein p53 binding protein 1
- Target synonyms53BP1; p202; p53-binding protein 1; p53BP1; TDRD30; TP53-binding protein 1; tumor protein 53-binding protein, 1; tumor suppressor p53-binding protein 1
- HostRabbit
- IsotypeIgG
- Scientific DescriptionThis gene encodes a protein that functions in the DNA double-strand break repair pathway choice, promoting non-homologous end joining (NHEJ) pathways, and limiting homologous recombination. This protein plays multiple roles in the DNA damage response, including promoting checkpoint signaling following DNA damage, acting as a scaffold for recruitment of DNA damage response proteins to damaged chromatin, and promoting NHEJ pathways by limiting end resection following a double-strand break. These roles are also important during V(D)J recombination, class switch recombination and at unprotected telomeres. Alternative splicing results in multiple transcript variants encoding different isoforms.
- ReactivityHuman, Mouse, Rat
- Storage Instruction-20°C
- UNSPSC12352203