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ProductsBack/5(S)-HEPE

5(S)-HEPE

ORB2283663

CAS Number92008-51-0

Product group Chemicals

Estimated Purity98.00%

Molecular Weight318.5

Overview

Supplier
Biorbyt
Product Name
5(S)-HEPE
Delivery Days Customer
10
CAS Number
92008-51-0
Certification
Research Use Only
Estimated Purity
98.00%
Molecular Formula
C20H30O3
Molecular Weight
318.5
Scientific Description
5(S)-HEPE, an active metabolite of eicosapentaenoic acid (EPA), is produced via the action of 5-lipoxygenase (5-LO). This compound functions as an agonist for G protein-coupled receptor 119 (GPR119), promoting cAMP accumulation in CHO-K1 cells expressing human GPR119 at 10 microM concentration. Additionally, 5(S)-HEPE enhances glucose-stimulated insulin secretion from MING6 insulinoma pancreatic islets and glucagon-like peptide 1 (GLP-1) secretion from HuTu 80 adenocarcinoma cells at the same concentration. Notably, serum levels of 5(S)-HEPE are increased in hyperlipidemia patients.
SMILES
[C@@H](/C=C/C=C\C/C=C\C/C=C\C/C=C\CC)(CCCC(O)=O)O
Storage Instruction
-20°C
UNSPSC
12352200

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