(5Z,2E)-CU-3

MedChem Express

(5Z,2E)-CU-3 [1815598-71-0]

10

1815598-71-0

Research Use Only

98.04

C16H12N2O4S3

392.47

(5Z,2E)-CU-3 is a potent and selective inhibitor against the alpha-isozyme of DGK with an IC 50 value of 0.6 microM, competitively inhibits the affinity of DGKalpha for ATP with a K m value of 0.48 mM. (5Z,2E)-CU-3 targets the catalytic region, but not the regulatory region of DGKalpha. (5Z,2E)-CU-3 has antitumoral and proimmunogenic effects, enhances the apoptosis of cancer cells and the activation of T cells [1] .

O=S(C1=CC=CC=C1)(NN(C/2=O)C(SC2=C/C=C/C3=CC=CO3)=S)=O

-20°C,2°C to 8°C

12352200