A-196

MedChem Express

A-196 [1982372-88-2]

5

1982372-88-2

Research Use Only

99.73

C18H16Cl2N4

359.25

A-196 is a potent and selective inhibitor of SUV420H1 and SUV420H2 with IC 50 values of 25 nM and 144 nM, respectively. A-196 inhibits SUV4-20 biochemically in a substrate-competitive manner. A-196 represents a first-in-class chemical probe of SUV4-20 to investigate the role of histone methyltransferases in genomic integrity [1] .

ClC1=C(Cl)C=C(C(C2=CC=NC=C2)=NN=C3NC4CCCC4)C3=C1

-20°C,2°C to 8°C

12352200