ac-DEVD-CMK [844499-71-4]

BPS Bioscience

A-769662

7

844499-71-4

Research Use Only

≥99%

C20H12N2O3S

360.4 Da

A-769662 is a potent, reversible activator of AMP-activated protein kinase (AMPK). AMPK is an alphabetagamma heterotrimer and plays an important role in regulating cellular and whole-body metabolism. A-769662 only activates AMPK heterotrimers containing the beta1 subunit. A-769662 activates AMPK through the beta subunit carbohydrate-binding module and the gamma subunit but not the AMP-binding sites. A-769662 stimulated partially purified rat liver AMPK with an EC50 of 0.8 microM and inhibited fatty acid synthesis in primary rat hepatocytes with an IC50 of 3.2 microM.

-20°C

51202000