Western blot analysis of extracts from COS7 cells, using AAK1 antibody.
Western blot analysis of extracts from COS7 cells, using AAK1 antibody.
AAK1 Antibody
CSB-PA903610
ApplicationsWestern Blot, ELISA
Product group Antibodies
ReactivityHuman, Mouse, Rat
TargetAAK1
Overview
- SupplierCusabio
- Product NameAAK1 Antibody
- Delivery Days Customer20
- ApplicationsWestern Blot, ELISA
- CertificationResearch Use Only
- ClonalityPolyclonal
- ConjugateUnconjugated
- Gene ID22848
- Target nameAAK1
- Target descriptionAP2 associated kinase 1
- Target synonymsadaptor-associated kinase 1; AP2-associated protein kinase 1
- HostRabbit
- IsotypeIgG
- Protein IDQ2M2I8
- Protein NameAP2-associated protein kinase 1
- Scientific DescriptionRegulates clathrin-mediated endocytosis by phosphorylating the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2) which ensures high affinity binding of AP-2 to cargo membrane proteins during the initial stages of endocytosis. Isoform 1 and isoform 2 display similar levels of kinase activity towards AP2M1. Regulates phosphorylation of other AP-2 subunits as well as AP-2 localization and AP-2-mediated internalization of ligand complexes. Phosphorylates NUMB and regulates its cellular localization, promoting NUMB localization to endosomes. Binds to and stabilizes the activated form of NOTCH1, increases its localization in endosomes and regulates its transcriptional activity. Kikuno R., DNA Res. 6:197-205(1999). Hillier L.W., Nature 434:724-731(2005). Beausoleil S.A., Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004).
- ReactivityHuman, Mouse, Rat
- Storage Instruction-20°C or -80°C
- UNSPSC12352203