AAK1 Antibody, FITC conjugated

Cusabio

AAK1 Antibody, FITC conjugated

20

Research Use Only

Polyclonal

FITC

AAK1

AP2 associated kinase 1

adaptor-associated kinase 1; AP2-associated protein kinase 1

Rabbit

IgG

AP2-associated protein kinase 1

Regulates clathrin-mediated endocytosis by phosphorylating the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2) which ensures high affinity binding of AP-2 to cargo membrane proteins during the initial stages of endocytosis. Isoform 1 and isoform 2 display similar levels of kinase activity towards AP2M1. Regulates phosphorylation of other AP-2 subunits as well as AP-2 localization and AP-2-mediated internalization of ligand complexes. Phosphorylates NUMB and regulates its cellular localization, promoting NUMB localization to endosomes. Binds to and stabilizes the activated form of NOTCH1, increases its localization in endosomes and regulates its transcriptional activity.

Human

-20°C or -80°C

12352203