Immunohistochemistry of paraffin-embedded Human liver cancer tissue using ABCC2 Polyclonal Antibody at dilution 1:45
Immunohistochemistry of paraffin-embedded Human liver cancer tissue using ABCC2 Polyclonal Antibody at dilution 1:45
ABCC2 Polyclonal Antibody
E-AB-17352
Product group Antibodies
Overview
- SupplierElabscience
- Product NameABCC2 Polyclonal Antibody
- Delivery Days Customer12
- CertificationResearch Use Only
- Scientific DescriptionThe protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine; therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia.
- UNSPSC12352203