ACBI1

AbMole BioScience

ACBI1

9

2375564-55-7

Chemical

Research Use Only

C49H58FN9O7S

936.12

ACBI1 is an effective and synergistic PROTAC inhibitor of SMARCA2, SMARCA4 and PBRM1, with DC50 of 6 nM, 11 nM and 32 nM in MV-4-11 cells, respectively. ACBI1 can induce antiproliferative effect and apoptosis.

CC1=C(SC=N1)C2=CC(=C(CNC(=O)C3CC(O)CN3C(=O)C(NC(=O)C4(F)CC4)C(C)(C)C)C=C2)OCCOC5=CC=C(CN6CCN(CC6)C7=C(N)N=NC(=C7)C8=C(O)C=CC=C8)C=C5

-20°C, protect from light, dry, sealed

12352200