Aconitase 1 antibody

GeneTex

Aconitase 1 antibody

9

WB: 1:500-1:3000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

Polyclonal

1 mg/ml

Unconjugated

ACO1

aconitase 1

ACONS, HEL60, IREB1, IREBP, IREBP1, IRP1, cytoplasmic aconitate hydratase, aconitase 1, soluble, aconitate hydratase, cytoplasmic, citrate hydro-lyase, cytoplasmic aconitase, cytosplasmic aconitase, epididymis luminal protein 60, epididymis secretory sperm binding protein, ferritin repressor protein, iron regulatory protein 1, iron-responsive element-binding protein 1, soluble aconitase

Rabbit

IgG

Cytoplasmic aconitate hydratase

Aconitase 1, also known as iron regulatory element binding protein 1 (IREB1), is a cytosolic protein which binds to iron-responsive elements (IREs). IREs are stem-loop structures found in the 5 UTR of ferritin mRNA, and in the 3 UTR of transferrin receptor mRNA. The iron-induced binding to the IRE results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degrading transferrin receptor mRNA. Thus, IREB1 plays a central role in cellular iron homeostasis. It was also shown to have aconitase activity, and hence grouped with the aconitase family of enzymes. [provided by RefSeq]

-20°C or -80°C,2°C to 8°C

12352203