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ProductsBack/Aconitase 2 antibody [C1C3]

Aconitase 2 antibody [C1C3]

Research Use Only
GTX109736
GeneTex
ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
DownloadDatasheet
Product group Antibodies
ReactivityHuman, Mouse, Rat
TargetACO2
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Overview

  • Supplier
    GeneTex
  • Product Name
    Aconitase 2 antibody [C1C3]
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:5000-1:20000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. IP: 1:100-1:500. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    0.82 mg/ml
  • Conjugate
    Unconjugated
  • Formulation
    Liquid
  • Gene ID50
  • Target name
    ACO2
  • Target description
    aconitase 2
  • Target synonyms
    aconitase 2, mitochondrial; aconitate hydratase, mitochondrial; ACONM; citrate hydro-lyase; epididymis secretory sperm binding protein Li 284; HEL-S-284; ICRD; mitochondrial aconitase; OCA8; OPA9
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDQ99798
  • Protein Name
    Aconitate hydratase, mitochondrial
  • Scientific Description
    The protein encoded by this gene belongs to the aconitase/IPM isomerase family. It is an enzyme that catalyzes the interconversion of citrate to isocitrate via cis-aconitate in the second step of the TCA cycle. This protein is encoded in the nucleus and functions in the mitochondrion. It was found to be one of the mitochondrial matrix proteins that are preferentially degraded by the serine protease 15(PRSS15), also known as Lon protease, after oxidative modification. [provided by RefSeq]
  • Reactivity
    Human, Mouse, Rat
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • A CRISPR screen identifies redox vulnerabilities for KEAP1/NRF2 mutant non-small cell lung cancer. Jiang C et al., 2022 Aug, Redox Biol
    Read more
  • Mitochondrial-Targeted Therapies Require Mitophagy to Prevent Oxidative Stress Induced by SOD2 Inactivation in Hypertrophied Cardiomyocytes. Peugnet V et al., 2022 Apr 6, Antioxidants (Basel)
    Read more
  • Nicotinamide nucleotide transhydrogenase regulates mitochondrial metabolism in NSCLC through maintenance of Fe-S protein function. Ward NP et al., 2020 Jun 1, J Exp Med
    Read more
  • Quercetin-induced cardioprotection against doxorubicin cytotoxicity. Chen JY et al., 2013 Dec 20, J Biomed Sci
    Read more