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Aconitase 2 antibody [C1C3]

Name: Aconitase 2 antibody [C1C3]
SKU: GTX109736_G10
Availability: BackOrder

GTX109736

ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Product group Antibodies

TargetACO2

Overview

Supplier
GeneTex
Product Name
Aconitase 2 antibody [C1C3]
Delivery Days Customer
9
Application Supplier Note
WB: 1:5000-1:20000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. IP: 1:100-1:500. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Applications
ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Certification
Research Use Only
Clonality
Polyclonal
Concentration
0.82 mg/ml
Conjugate
Unconjugated
Gene ID50
Target name
ACO2
Target description
aconitase 2
Target synonyms
ACONM, HEL-S-284, ICRD, OCA8, OPA9, aconitate hydratase, mitochondrial, aconitase 2, mitochondrial, citrate hydro-lyase, epididymis secretory sperm binding protein Li 284, mitochondrial aconitase
Host
Rabbit
Isotype
IgG
Protein IDQ99798
Protein Name
Aconitate hydratase, mitochondrial
Scientific Description
The protein encoded by this gene belongs to the aconitase/IPM isomerase family. It is an enzyme that catalyzes the interconversion of citrate to isocitrate via cis-aconitate in the second step of the TCA cycle. This protein is encoded in the nucleus and functions in the mitochondrion. It was found to be one of the mitochondrial matrix proteins that are preferentially degraded by the serine protease 15(PRSS15), also known as Lon protease, after oxidative modification. [provided by RefSeq]
Storage Instruction
-20°C or -80°C,2°C to 8°C
UNSPSC
12352203

Jiang C, Ward NP, Prieto-Farigua N, et al. A CRISPR screen identifies redox vulnerabilities for KEAP1/NRF2 mutant non-small cell lung cancer. Redox Biol. 2022,54:102358. doi: 10.1016/j.redox.2022.102358
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Peugnet V, Chwastyniak M, Mulder P, et al. Mitochondrial-Targeted Therapies Require Mitophagy to Prevent Oxidative Stress Induced by SOD2 Inactivation in Hypertrophied Cardiomyocytes. Antioxidants (Basel). 2022,11(4). doi: 10.3390/antiox11040723
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Ward NP, Kang YP, Falzone A, et al. Nicotinamide nucleotide transhydrogenase regulates mitochondrial metabolism in NSCLC through maintenance of Fe-S protein function. J Exp Med. 2020,217(6). doi: 10.1084/jem.20191689
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Chen JY, Hu RY, Chou HC. Quercetin-induced cardioprotection against doxorubicin cytotoxicity. J Biomed Sci. 2013,20(1):95. doi: 10.1186/1423-0127-20-95
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