ACP-5862 [2230757-47-6]

MedChem Express

ACP-5862 [2230757-47-6]

9

2230757-47-6

Research Use Only

98.41

C26H23N7O3

481.51

ACP-5862 is a major active, circulating, pyrrolidine ring-opened metabolite of Acalabrutinib with an IC50 of 5.0 nM for Bruton tyrosine kinase (BTK). ACP-5862 is a weak time-dependent inactivator of CYP3A4 and CYP2C8. Acalabrutinib is an orally active, irreversible, and highly selective BTK inhibitor, with an IC50 of 3 nM and EC50 of 8 nM[1][2].

O=C(NC1=NC=CC=C1)C2=CC=C(C3=C4C(N)=NC=CN4C(C(CCCNC(C#CC)=O)=O)=N3)C=C2

-20°C,2°C to 8°C

12352200