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ProductsBack/Actinonin [13434-13-4]
Chemical Structure
Chemical Structure
Chemical Structure

Actinonin [13434-13-4]

Research Use Only
AG-CN2-0161
AdipoGen Life Sciences
CAS Number13434-13-4
DownloadMSDS
Product group Chemicals
Estimated Purity>97%
Molecular Weight385.5
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    Actinonin
  • Delivery Days Customer
    10
  • CAS Number
    13434-13-4
  • Certification
    Research Use Only
  • Estimated Purity
    >97%
  • Molecular Formula
    C19H35N3O5
  • Molecular Weight
    385.5
  • Scientific Description
    Antibiotic. Aminopeptidase M, N and leucine and alanine aminopeptidase inhibitor. Potent peptide deformylase (PDF) inhibitor. Inhibits MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-12 and MMP-13, but not MMP-14. Anticancer compound. Antiproliferative. Shows antitumor activity in vitro and in vivo. Apoptosis inducer. Meprin A inhibitor. - Chemical. CAS: 13434-13-4. Formula: C19H35N3O5. MW: 385.5. Synthetic. Antibiotic. Aminopeptidase M, N and leucine and alanine aminopeptidase inhibitor. Potent peptide deformylase (PDF) inhibitor. Inhibits MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-12 and MMP-13, but not MMP-14. Anticancer compound. Antiproliferative. Shows antitumor activity in vitro and in vivo Apoptosis inducer. Meprin A inhibitor.
  • SMILES
    CCCCCC(CC(=O)NO)C(=O)NC(C(C)C)C(=O)N1CCCC1CO
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352200

References

  • Actinonin: an antibiotic substance produced by an actinomycete: J.J. Gordon, et al.; Nature 195, 701 (1962)
  • Production of actinonin, an inhibitor of aminopeptidase M, by actinomycetes: H. Umezawa, et al.; J. Antibiot. 38, 1629 (1985)
  • Analgesic effect of actinonin, a new potent inhibitor of multiple enkephalin degrading enzymes: M. Hachisu, et al.; Life Sci. 41, 235 (1987)
  • Antitumor activity of actinonin in vitro and in vivo: Y. Xu, et al.; Clin. Cancer Res. 4, 171 (1998)
  • Actinonin, a naturally occurring antibacterial agent, is a potent deformylase inhibitor: D.Z. Chen, et al.; Biochemistry 39, 1256 (2000)
  • Actinonin induces apoptosis in U937 leukemia cells: M. Grujic, et al.; Cancer Lett. 223, 211 (2004)
  • Actinonin, a meprin inhibitor, protects ischemic acute kidney injury in male but not in female rats: J. Takayama, et al.; Eur. J. Pharmacol. 581, 157 (2007)
  • Actinonin, a meprin A inhibitor, protects the renal microcirculation during sepsis: Z. Whang, et al.; Shock 35, 141 (2011)