Western blot analysis of extracts of various cell lines using ACTL6A Polyclonal Antibody at dilution of 1:1000.
Western blot analysis of extracts of various cell lines using ACTL6A Polyclonal Antibody at dilution of 1:1000.
ACTL6A Polyclonal Antibody
E-AB-60939
Product group Antibodies
Overview
- SupplierElabscience
- Product NameACTL6A Polyclonal Antibody
- Delivery Days Customer12
- CertificationResearch Use Only
- Scientific DescriptionThis gene encodes a family member of actin-related proteins (ARPs), which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene encodes a 53 kDa subunit protein of the BAF (BRG1/brm-associated factor) complex in mammals, which is functionally related to SWI/SNF complex in S. cerevisiae and Drosophila; the latter is thought to facilitate transcriptional activation of specific genes by antagonizing chromatin-mediated transcriptional repression. Together with beta-actin, it is required for maximal ATPase activity of BRG1, and for the association of the BAF complex with chromatin/matrix. Three transcript variants that encode two different protein isoforms have been described.
- UNSPSC12352203