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Adezmapimod

HY-10256
MedChem Express
CAS Number152121-47-6
Product group Chemicals
Estimated Purity99.96
Molecular Weight377.43
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Overview

  • Supplier
    MedChem Express
  • Product Name
    Adezmapimod [152121-47-6]
  • Delivery Days Customer
    10
  • CAS Number
    152121-47-6
  • Certification
    Research Use Only
  • Estimated Purity
    99.96
  • Molecular Formula
    C21H16FN3OS
  • Molecular Weight
    377.43
  • Scientific Description
    Adezmapimod (SB 203580) is a selective and ATP-competitive p38 MAPK inhibitor with IC 50 s of 50 nM and 500 nM for SAPK2a/p38 and SAPK2b/p38beta2 , respectively. Adezmapimod inhibits LCK, GSK3beta and PKBalpha with IC 50 s of 100-500-fold higher than that for SAPK2a/p38. Adezmapimod does not disrupt JNK activity and is an autophagy and mitophagy activator [1] .
  • SMILES
    O=S(C1=CC=C(C2=NC(C3=CC=C(F)C=C3)=C(C4=CC=NC=C4)N2)C=C1)C
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352200

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