ProductsBack/AF647 Anti-Human CD45RO Antibody

AF647 Anti-Human CD45RO Antibody

RD21727F

ApplicationsFlow Cytometry

Product group Antibodies

TargetPTPRC

Overview

Supplier
Reddot Biotech
Product Name
AF647 Anti-Human CD45RO Antibody
Delivery Days Customer
5
Applications
Flow Cytometry
Certification
Research Use Only
Clonality
Monoclonal
Clone ID
UCHL1
Conjugate
AlexaFluor 647
Gene ID5788
Target name
PTPRC
Target description
protein tyrosine phosphatase receptor type C
Target synonyms
B220; CD45; CD45 antigen; CD45R; GP180; LCA; L-CA; LY5; protein tyrosine phosphatase, receptor type, c polypeptide; receptor-type tyrosine-protein phosphatase C; T200; T200 glycoprotein; T200 leukocyte common antigen
Host
Mouse
Isotype
IgG2a
Scientific Description
CD45RO is a 180 kD single chain membrane glycoprotein. It is a splice variant of tyrosine phosphatase CD45, lacking the A, B, and C determinants. The CD45RO isoform is expressed on activated and memory T cells, some B cell subsets, activated monocytes/macrophages, and granulocytes. CD45RO enhances both T cell receptor and B cell receptor signaling mediated activation. CD45 and its isoforms non-covalently associate with lymphocyte phosphatase-associated phosphoprotein (LPAP) on T and B lymphocytes. CD45 has been reported to be associated with several other cell surface antigens including CD1, CD2, CD3, and CD4. CD45 has also been reported to bind galectin-1 and CD22. CD45 isoform expression can change in response to cytokines.
Storage Instruction
2°C to 8°C
UNSPSC
12352203

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