Afizagabar [1398496-82-6]

MedChem Express

Afizagabar [1398496-82-6]

10

1398496-82-6

Research Use Only

98.40

C19H12FN3O2S

365.38

Afizagabar (S44819) is a first-in-class, competitive, and selective antagonist at the GABA-binding site of the alpha5-GABAAR, with an IC50 of 585 nM for alpha5beta2gamma2 and a Ki of 66 nM for alpha5beta3gamma2. Afizagabar enhances hippocampal synaptic plasticity and exhibits pro-cognitive efficacy[1].

O=C(N1)OC2=C1C=C3CC(C)=NN=C(C4=CC5=C(F)C=CC=C5S4)C3=C2

-20°C,2°C to 8°C

12352200