Afizagabar [1398496-82-6]

TargetMol Chemicals

Afizagabar [1398496-82-6]

86

1398496-82-6

Research Use Only

Afizagabar

C19H12FN3O2S

365.38

Afizagabar (S44819) is a first-in-class, competitive, and selective antagonist at the GABA-binding site of the alpha5-GABAAR, with an IC50 of 585 nM for alpha5beta2gamma2 and a Ki of 66 nM for alpha5beta3gamma2. It enhances hippocampal synaptic plasticity and exhibits pro-cognitive efficacy [1].

3 years

CC1=NN=C(c2cc3c(F)cccc3s2)c2cc3oc(=O)[nH]c3cc2C1

-20°C

12352200