Bio-Connect

AGO2 (N2) Antibody, Rabbit Polyclonal

ORB67055
Biorbyt
TargetAGO2
Product group Antibodies
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Overview

  • Supplier
    Biorbyt
  • Product Name
    AGO2 antibody
  • Delivery Days Customer
    16
  • Applications Supplier
    WB:1:1000-1:5000 WB
  • Gene ID27161
  • Target name
    AGO2
  • Target description
    argonaute RISC catalytic component 2
  • Target synonyms
    argonaute 2, RISC catalytic component; cancer susceptibility candidate 7 (non-protein coding); CASC7; EIF2C2; eukaryotic translation initiation factor 2C, 2; LESKRES; LINC00980; long intergenic non-protein coding RNA 980; PAZ Piwi domain protein; PPD; protein argonaute-2; protein slicer; Q10
  • Protein IDQ9UKV8
  • Protein Name
    Protein argonaute-2
  • Scientific Description
    Rabbit polyclonal to AGO2.Protein argonaute-2 (AGO2) is also known as Eukaryotic translation initiation factor 2C 2 (EIF2C2),which is required for RNA-mediated gene silencing NAi) by the RNA-induced silencing complexISC). The minimal RISC appears to include EIF2C2/AGO2 bound to a short guide RNA such as amicroRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC tocomplementary mRNAs that are targets for RISC-mediated gene silencing. Binding of RISC to aperfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of themRNA specifically by EIF2C2/AGO2. The inhibition of translational initiation leads to the accumulationof the affected mRNA in cytoplasmic processing bodies (P-bodies), where mRNA degradation maysubsequently occur.
  • Storage Instruction
    -20°C
  • UNSPSC
    12352203