AIF peptide

GeneTex

AIF peptide

9

The peptide is used for blocking the antibody activity of AIF. It usuallyblocks the antibody activity completely in Western blot by incubating the peptide with equalvolume of antibody for 30 min at 37C

Neutralisation/Blocking

Research Use Only

0.20 mg/ml

Unconjugated

Liquid

Apoptosis-inducing factor 1, mitochondrial

This gene encodes a flavoprotein essential for nuclear disassembly in apoptotic cells, and it is found in the mitochondrial intermembrane space in healthy cells. Induction of apoptosis results in the translocation of this protein to the nucleus where it affects chromosome condensation and fragmentation. In addition, this gene product induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. Mutations in this gene cause combined oxidative phosphorylation deficiency 6 (COXPD6), a severe mitochondrial encephalomyopathy, as well as Cowchock syndrome, also known as X-linked recessive Charcot-Marie-Tooth disease-4 (CMTX-4), a disorder resulting in neuropathy, and axonal and motor-sensory defects with deafness and cognitive disability. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 10. [provided by RefSeq, Aug 2015]

-20°C

12352202