AKAP10 Antibody

Cusabio

AKAP10 Antibody

20

Western Blot, ELISA, ImmunoHistoChemistry

Research Use Only

Polyclonal

Unconjugated

AKAP10

A-kinase anchoring protein 10

AKAP-10, D-AKAP-2, D-AKAP2, PRKA10, A-kinase anchor protein 10, mitochondrial, A kinase (PRKA) anchor protein 10, dual specificity A kinase-anchoring protein 2, mitochondrial A kinase PPKA anchor protein 10, protein kinase A anchoring protein 10

Rabbit

IgG

A-kinase anchor protein 10, mitochondrial

Differentially targeted protein that binds to type I and II regulatory subunits of protein kinase A and anchors them to the mitochondria or the plasma membrane. Although the physiological relevance between PKA and AKAPS with mitochondria is not fully understood, one idea is that BAD, a proapoptotic member, is phosphorylated and inactivated by mitochondria-anchored PKA. It cannot be excluded too that it may facilitate PKA as well as G protein signal transduction, by acting as an adapter for assembling multiprotein complexes. With its RGS domain, it could lead to the interaction to G-alpha proteins, providing a link between the signaling machinery and the downstream kinase (By similarity).

Human

-20°C or -80°C

41116161