AKT antibody
GTX28805
ApplicationsFlow Cytometry, ImmunoFluorescence, Western Blot, ELISA, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
Overview
- SupplierGeneTex
- Product NameAKT antibody
- Delivery Days Customer9
- Application Supplier NoteWB: 1:500-1:2000. ICC/IF: 1:100-1:1000. IHC-P: 1:500-1:2000. ELISA: 1:2000-1:10000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsFlow Cytometry, ImmunoFluorescence, Western Blot, ELISA, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration85 mg/ml
- ConjugateUnconjugated
- HostRabbit
- IsotypeIgG
- Scientific DescriptionAkt (Protein Kinase B, PKB) is a key regulator of many signal transduction pathways (reviewed in ref 1). Its tight control over cell proliferation and cell viability are manifold; overexpression or inappropriate activation of Akt has been seen in many types of cancer. Akt mediates many of the downstream events of PI 3-kinase (a lipid kinase activated by growth factors, cytokines and insulin). PI 3-kinase recruits Akt to the membrane, where it is activated by PDK1 phosphorylation (reviewed in 2). Once phosphorylated, Akt dissociates from the membrane and phosphorylates targets in the cytoplasm and the cell nucleus. Akt has two main roles: (i) inhibition of apoptosis; (ii) promotion of proliferation.
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- DDTC Suppresses Ovarian Cancer Development via the PI3K/AKT/mTOR Signaling Pathway.Read more
- The Mechanism of Xiaoyao San in the Treatment of Ovarian Cancer by Network Pharmacology and the Effect of Stigmasterol on the PI3K/Akt Pathway. Li M et al., 2021, Dis MarkersRead more
- MAPK, AKT/FoxO3a and mTOR pathways are involved in cadmium regulating the cell cycle, proliferation and apoptosis of chicken follicular granulosa cells. Zhu M et al., 2021 May, Ecotoxicol Environ SafRead more
- Orchiectomy and letrozole differentially regulate synaptic plasticity and spatial memory in a manner that is mediated by SRC-1 in the hippocampus of male mice. Zhao J et al., 2018 Apr, J Steroid Biochem Mol BiolRead more
- PFKFB3 modulates glycolytic metabolism and alleviates endoplasmic reticulum stress in human osteoarthritis cartilage. Qu J et al., 2016 Mar, Clin Exp Pharmacol PhysiolRead more
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![WB analysis of NIH3T3 (1), HeLa (2),COS7 (3) and Jurkat (4) cell lysate using GTX82762 AKT1 antibody [3A3].](https://www.genetex.com/upload/website/prouct_img/normal/GTX82762/GTX82762_20170912_WB_w_23061322_461.webp)
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