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ProductsBack/AKT (phospho Ser473) antibody [104A282] - Orthogonal Validated
IHC-P analysis of human breast carcinoma tissue using GTX11901 AKT (phospho Ser473) antibody [104A282]. Dilution : 1:250 Antigen retrieval : Heat induced antigen retrieval (HIER) using 10mM sodium citrate buffer (pH 6.0)
IHC-P analysis of human breast carcinoma tissue using GTX11901 AKT (phospho Ser473) antibody [104A282]. Dilution : 1:250 Antigen retrieval : Heat induced antigen retrieval (HIER) using 10mM sodium citrate buffer (pH 6.0)
IHC-P analysis of human breast carcinoma tissue using GTX11901 AKT (phospho Ser473) antibody [104A282]. Dilution : 1:250 Antigen retrieval : Heat induced antigen retrieval (HIER) using 10mM sodium citrate buffer (pH 6.0)

AKT (phospho Ser473) antibody [104A282] - Orthogonal Validated

Research Use Only
GTX11901
GeneTex
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
DownloadDatasheet
Product group Antibodies
ReactivityChicken, Human, Mouse, Zebra Fish
TargetAKT1
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Overview

  • Supplier
    GeneTex
  • Product Name
    AKT (phospho Ser473) antibody [104A282] - Orthogonal Validated
  • Delivery Days Customer
    9
  • Applications
    ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    104A282
  • Concentration
    1 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID207
  • Target name
    AKT1
  • Target description
    AKT serine/threonine kinase 1
  • Target synonyms
    AKT; AKT1m; PKB; PKB alpha; PKB-ALPHA; PRKBA; protein kinase B alpha; proto-oncogene c-Akt; RAC; rac protein kinase alpha; RAC-ALPHA; RAC-alpha serine/threonine-protein kinase; RAC-PK-alpha; serine-threonine protein kinase; v-akt murine thymoma viral oncogene homolog 1; v-akt murine thymoma viral oncogene-like protein 1
  • Host
    Mouse
  • Isotype
    IgG1
  • Modification Type
    Phosphorylated
  • Scientific Description
    The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq]
  • Reactivity
    Chicken, Human, Mouse, Zebra Fish
  • Storage Instruction
    2°C to 8°C,-20°C or -80°C
  • UNSPSC
    12352203

References

  • High Mobility Group A 1 Expression as a Poor Prognostic Marker Associated with Tumor Invasiveness in Gastric Cancer. Chang HP et al., 2022 May 9, Life (Basel)
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  • The synthetic flavonoid WYC02-9 inhibits cervical cancer cell migration/invasion and angiogenesis via MAPK14 signaling. Chen YJ et al., 2013 Dec, Gynecol Oncol
    Read more
  • Antiparallel segregation of notch components in the immunological synapse directs reciprocal signaling in allogeneic Th:DC conjugates. Luty WH et al., 2007 Jul 15, J Immunol
    Read more
  • Silencing of caspase-8 and caspase-3 by RNA interference prevents vascular endothelial cell injury in mice with endotoxic shock. Matsuda N et al., 2007 Oct 1, Cardiovasc Res
    Read more