Alkaline Phosphatase (Tissue Non-Specific) antibody
GTX100817
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Mouse, Sheep
TargetALPL
Overview
- SupplierGeneTex
- Product NameAlkaline Phosphatase (Tissue Non-Specific) antibody
- Delivery Days Customer9
- ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration1.76 mg/ml
- ConjugateUnconjugated
- Gene ID249
- Target nameALPL
- Target descriptionalkaline phosphatase, biomineralization associated
- Target synonymsalkaline phosphatase liver/bone/kidney isozyme; alkaline phosphatase, liver/bone/kidney; alkaline phosphatase, tissue-nonspecific isozyme; APTNAP; AP-TNAP; HOPS; HPPA; HPPC; HPPI; HPPO; liver/bone/kidney-type alkaline phosphatase; tissue non-specific alkaline phosphatase; tissue-nonspecific ALP; TNALP; TNAP; TNSALP
- HostRabbit
- IsotypeIgG
- Scientific DescriptionThere are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. The exact physiological function of the alkaline phosphatases is not known. A proposed function of this form of the enzyme is matrix mineralization; however, mice that lack a functional form of this enzyme show normal skeletal development. This enzyme has been linked directly to hypophosphatasia, a disorder that is characterized by hypercalcemia and includes skeletal defects. The character of this disorder can vary, however, depending on the specific mutation since this determines age of onset and severity of symptoms. Alternatively spliced transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq]
- ReactivityHuman, Mouse, Sheep
- Storage Instruction2°C to 8°C,-20°C or -80°C
- UNSPSC12352203
References
- Personalized medicine for reconstruction of critical-size bone defects - a translational approach with customizable vascularized bone tissue. Kengelbach-Weigand A et al., 2021 Aug 19, NPJ Regen MedRead more
- PP2A in LepR+ mesenchymal stem cells contributes to embryonic and postnatal endochondral ossification through Runx2 dephosphorylation. Yen YT et al., 2021 Jun 2, Commun BiolRead more
- Effects of cadmium on osteoblast cell line: Exportin 1 accumulation, p-JNK activation, DNA damage and cell apoptosis. Ou L et al., 2021 Jan 15, Ecotoxicol Environ SafRead more
- Ex-vivo recellularisation and stem cell differentiation of a decellularised rat dental pulp matrix. Matoug-Elwerfelli M et al., 2020 Dec 9, Sci RepRead more
- The Role of Osteocalcin and Alkaline Phosphatase Immunohistochemistry in Osteosarcoma Diagnosis. Agustina H et al., 2018, Patholog Res IntRead more
- Du-Huo-Ji-Sheng-Tang and its active component Ligusticum chuanxiong promote osteogenic differentiation and decrease the aging process of human mesenchymal stem cells. Wang JY et al., 2017 Feb 23, J EthnopharmacolRead more
- Bone Tissue Engineering Under Xenogeneic-Free Conditions in a Large Animal Model as a Basis for Early Clinical Applicability. Weigand A et al., 2017 Mar, Tissue Eng Part ARead more
- Autologous serum improves bone formation in a primary stable silica-embedded nanohydroxyapatite bone substitute in combination with mesenchymal stem cells and rhBMP-2 in the sheep model. Boos AM et al., 2014, Int J NanomedicineRead more
- N-cadherin in osteolineage cells is not required for maintenance of hematopoietic stem cells. Greenbaum AM et al., 2012 Jul 12, BloodRead more