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ProductsBack/Alpelisib [1217486-61-7]

Alpelisib [1217486-61-7]

Research Use Only
SYN-1230
SYNkinase
CAS Number1217486-61-7
Product group Chemicals
Estimated Purity>95%
Molecular Weight441.5
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Overview

  • Supplier
    SYNkinase
  • Product Name
    Alpelisib [1217486-61-7]
  • Delivery Days Customer
    10
  • CAS Number
    1217486-61-7
  • Certification
    Research Use Only
  • Estimated Purity
    >95%
  • Molecular Formula
    C19H22F3N5O2S
  • Molecular Weight
    441.5
  • Scientific Description
    Chemical. CAS: 1217486-61-7. Formula: C19H22F3N5O2S. MW: 441.5. Selective PI3Kalpha inhibitor with IC50 of 5nM. Has minimal effect on other PI3K isoforms. Exhibits favorable pharmacokinetics and excellent oral bioavailability in animal models. In xenografts using nude mice, it showed dose-dependent effects of tumour inhibition. In a phase Ib study, it showed synergistic anti-tumor activity with endocrine therapy against ER+/PIK3CA mutated breast cancer cells. - Selective PI3Kalpha inhibitor with IC50 of 5nM. Has minimal effect on other PI3K isoforms. Exhibits favorable pharmacokinetics and excellent oral bioavailability in animal models. In xenografts using nude mice, it showed dose-dependent effects of tumour inhibition. In a phase Ib study, it showed synergistic anti-tumor activity with endocrine therapy against ER+/PIK3CA mutated breast cancer cells.
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    51202000