alpha Actinin 1 antibody [0.T.02]

GeneTex

alpha Actinin 1 antibody [0.T.02]

9

Recognizes human alpha-Actinin 1 isoform (non-muscle) at 100kD.

WB: 0.5-2microg/ml. ICC/IF: 15microg/ml (fixed with methanol). IHC-Fr: 15microg/ml. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen

Research Use Only

Monoclonal

0.T.02

Unconjugated

Liquid

ACTN1

actinin alpha 1

actinin 1 smooth muscle; alpha-actinin-1; BDPLT15; epididymis secretory sperm binding protein; F-actin cross-linking protein; non-muscle alpha-actinin-1

Mouse

IgG1

Alpha-actinin-1

Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Human, Mouse, Rat, Xenopus

-20°C or -80°C,2°C to 8°C

12352203