GTX18061 WB Image
alpha Actinin 1 antibody [0.T.02]
GTX18061
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen
Product group Antibodies
ReactivityHuman, Mouse, Rat, Xenopus
Overview
- SupplierGeneTex
- Product Namealpha Actinin 1 antibody [0.T.02]
- Delivery Days Customer10
- ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone ID0.T.02
- HostMouse
- IsotypeIgG
- Scientific DescriptionAlpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
- ReactivityHuman, Mouse, Rat, Xenopus
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203
References
- Kindlin-1 Is required for RhoGTPase-mediated lamellipodia formation in keratinocytes. Has C et al., 2009 Oct, Am J PatholRead more