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ProductsBack/alpha-Galactosylceramide (Dansylated)
Chemical Structure
Chemical Structure
Chemical Structure

alpha-Galactosylceramide (Dansylated)

Research Use Only
AG-CN2-0514
AdipoGen Life Sciences
Estimated Purity>95%
DownloadMSDS
Product group Chemicals
Molecular Weight1090.6
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    alpha-Galactosylceramide (Dansylated)
  • Delivery Days Customer
    10
  • Certification
    Research Use Only
  • Estimated Purity
    >95%
  • Molecular Formula
    C62H111N3O10S
  • Molecular Weight
    1090.6
  • Scientific Description
    Chemical. CAS: 424823-23-4. Formula: C62H111N3O10S. MW: 1090.6. Fluorescent alpha-GalCer derivative. Potent stimulator of invariant natural killer T (iNKT) cells similar to alpha-GalCer (determined by CD86 expression in DCs and B cells, and IL-2 production by iNKT cells). Specific ligand of the lipid-binding MHC class I-like protein CD1d in human and mouse NKT cells. Used as a fluorescent marker for the uptake of the glycolipid by dendritic cells (DCs) in vitro and to better understand the mechanism of iNKT cell activation. - Fluorescent alpha-GalCer derivative. Potent stimulator of invariant natural killer T (iNKT) cells similar to alpha-GalCer (determined by CD86 expression in DCs and B cells, and IL-2 production by iNKT cells). Specific ligand of the lipid-binding MHC class I-like protein CD1d in human and mouse NKT cells. Used as a fluorescent marker for the uptake of the glycolipid by dendritic cells (DCs) in vitro and to better understand the mechanism of iNKT cell activation.
  • SMILES
    O[C@H]1[C@@H](O)[C@@H](CNS(C2=CC=CC3=C2C=CC=C3N(C)C)(=O)=O)O[C@H](OC[C@@H]([C@@H]([C@@H](CCCCCCCCCCCCCC)O)O)NC(CCCCCCCCCCCCCCCCCCCCCCCCC)=O)[C@@H]1O
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352200

References

  • Synthesis and NKT cell stimulating properties of fluorophore- and biotin-appended 6''-amino-6''-deoxy- galactosylceramides: X.-T. Zhou, et al.; Org. Lett. 4, 1267 (2002)
  • An improved synthesis of dansylated alpha-galactosylceramide and its use as a fluorescent probe for the monitoring of glycolipid uptake by cells: J.M.H. Cheng, et al.; Carbohydr. Res. 346, 914 (2011)
  • Trehalose diesters, lipoteichoic acids and alpha-GalCer: using chemistry to understand immunology: B.L. Stocker & M.S.M. Timmer; Carbohydr. Res. 389, 3 (2014)