ProductsBack/alpha Synuclein (phospho Ser129) antibody

WB analysis of extracts from mouse brain tissue using GTX50222 alpha Synuclein (phospho Ser129) antibody. Lane 1 : Primary antibody pre-incubated with the antigen specific peptide

alpha Synuclein (phospho Ser129) antibody

GTX50222

ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry

Product group Antibodies

ReactivityHuman, Mouse, Rat

TargetSNCA

Overview

Supplier
GeneTex
Product Name
alpha Synuclein (phospho Ser129) antibody
Delivery Days Customer
9
Application Supplier Note
WB: 1:500-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Applications
ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry
Certification
Research Use Only
Clonality
Polyclonal
Concentration
1 mg/ml
Conjugate
Unconjugated
Gene ID6622
Target name
SNCA
Target description
synuclein alpha
Target synonyms
NACP, PARK1, PARK4, PD1, alpha-synuclein, I+/--synuclein, non A-beta component of AD amyloid, synuclein alpha-140, synuclein, alpha (non A4 component of amyloid precursor)
Host
Rabbit
Isotype
IgG
Protein IDP37840
Protein Name
Alpha-synuclein
Scientific Description
Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimers disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2016]
Reactivity
Human, Mouse, Rat
Storage Instruction
-20°C or -80°C,2°C to 8°C
UNSPSC
12352203

References

Chiu YS, Wu KJ, Yu SJ, et al. Peptide immunization against the C-terminal of alpha-synuclein reduces locomotor activity in mice overexpressing alpha-synuclein. PLoS One. 2023,18(9):e0291927. doi: 10.1371/journal.pone.0291927
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Howe JW, Sortwell CE, Duffy MF, et al. Preformed fibrils generated from mouse alpha-synuclein produce more inclusion pathology in rats than fibrils generated from rat alpha-synuclein. Parkinsonism Relat Disord. 2021,89:41-47. doi: 10.1016/j.parkreldis.2021.06.010
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Miller KM, Patterson JR, Kochmanski J, et al. Striatal Afferent BDNF Is Disrupted by Synucleinopathy and Partially Restored by STN DBS. J Neurosci. 2021,41(9):2039-2052. doi: 10.1523/JNEUROSCI.1952-20.2020
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Chung E, Choi Y, Park J, et al. Intracellular delivery of Parkin rescues neurons from accumulation of damaged mitochondria and pathological α-synuclein. Sci Adv. 2020,6(18):eaba1193. doi: 10.1126/sciadv.aba1193
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Rocha EM, De Miranda BR, Castro S, et al. LRRK2 inhibition prevents endolysosomal deficits seen in human Parkinson's disease. Neurobiol Dis. 2020,134:104626. doi: 10.1016/j.nbd.2019.104626
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Xia Y, Zhang G, Han C, et al. Microglia as modulators of exosomal alpha-synuclein transmission. Cell Death Dis. 2019,10(3):174. doi: 10.1038/s41419-019-1404-9
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Grassi D, Howard S, Zhou M, et al. Identification of a highly neurotoxic α-synuclein species inducing mitochondrial damage and mitophagy in Parkinson's disease. Proc Natl Acad Sci U S A. 2018,115(11):E2634-E2643. doi: 10.1073/pnas.1713849115
Read this paper
Landrock KK, Sullivan P, Martini-Stoica H, et al. Pleiotropic neuropathological and biochemical alterations associated with Myo5a mutation in a rat Model. Brain Res. 2018,1679:155-170. doi: 10.1016/j.brainres.2017.11.029
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alpha Synuclein (phospho Ser129) antibody

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