WB analysis of extracts from mouse brain tissue using GTX50222 alpha Synuclein (phospho Ser129) antibody. Lane 1 : Primary antibody pre-incubated with the antigen specific peptide
WB analysis of extracts from mouse brain tissue using GTX50222 alpha Synuclein (phospho Ser129) antibody. Lane 1 : Primary antibody pre-incubated with the antigen specific peptide
alpha Synuclein (phospho Ser129) antibody
GTX50222
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry
Product group Antibodies
ReactivityHuman, Mouse, Rat
TargetSNCA
Overview
- SupplierGeneTex
- Product Namealpha Synuclein (phospho Ser129) antibody
- Delivery Days Customer9
- Application Supplier NoteWB: 1:500-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration1 mg/ml
- ConjugateUnconjugated
- FormulationLiquid
- Gene ID6622
- Target nameSNCA
- Target descriptionsynuclein alpha
- Target synonymsalpha-synuclein; I+/--synuclein; NACP; non A-beta component of AD amyloid; PARK1; PARK4; PD1; synuclein alpha-140; synuclein, alpha (non A4 component of amyloid precursor); truncated alpha synuclein
- HostRabbit
- IsotypeIgG
- Modification TypePhosphorylated
- Protein IDP37840
- Protein NameAlpha-synuclein
- Scientific DescriptionAlpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimers disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2016]
- ReactivityHuman, Mouse, Rat
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- Striatal Afferent BDNF Is Disrupted by Synucleinopathy and Partially Restored by STN DBS. Miller KM et al., 2021 Mar 3, J NeurosciRead more
- Intracellular delivery of Parkin rescues neurons from accumulation of damaged mitochondria and pathological alpha-synuclein. Chung E et al., 2020 May, Sci AdvRead more
- LRRK2 inhibition prevents endolysosomal deficits seen in human Parkinsons disease. Rocha EM et al., 2020 Feb, Neurobiol DisRead more
- Microglia as modulators of exosomal alpha-synuclein transmission. Xia Y et al., 2019 Feb 20, Cell Death DisRead more
- Identification of a highly neurotoxic alpha-synuclein species inducing mitochondrial damage and mitophagy in Parkinsons disease. Grassi D et al., 2018 Mar 13, Proc Natl Acad Sci U S ARead more
- Pleiotropic neuropathological and biochemical alterations associated with Myo5a mutation in a rat Model. Landrock KK et al., 2018 Jan 15, Brain ResRead more