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ICC/IF analysis of formalin-fixed HEK293T cells using GTX54991 alpha Synuclein (phospho Ser129) antibody. Red : Primary antibody Blue : DAPI Permeabilization : 0.1% Triton X-100 in TBS for 5-10 minutes
ICC/IF analysis of formalin-fixed HEK293T cells using GTX54991 alpha Synuclein (phospho Ser129) antibody. Red : Primary antibody Blue : DAPI Permeabilization : 0.1% Triton X-100 in TBS for 5-10 minutes
ICC/IF analysis of formalin-fixed HEK293T cells using GTX54991 alpha Synuclein (phospho Ser129) antibody. Red : Primary antibody Blue : DAPI Permeabilization : 0.1% Triton X-100 in TBS for 5-10 minutes

alpha Synuclein (phospho Ser129) antibody

GTX54991
GeneTex
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin
Product group Antibodies
TargetSNCA
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Overview

  • Supplier
    GeneTex
  • Product Name
    alpha Synuclein (phospho Ser129) antibody
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:500 - 1:1000. ICC/IF: 1:100 - 1:500. IHC-P: 1:100 - 1:200. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Conjugate
    Unconjugated
  • Gene ID6622
  • Target name
    SNCA
  • Target description
    synuclein alpha
  • Target synonyms
    NACP, PARK1, PARK4, PD1, alpha-synuclein, I+/--synuclein, non A-beta component of AD amyloid, synuclein alpha-140, synuclein, alpha (non A4 component of amyloid precursor)
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDP37840
  • Protein Name
    Alpha-synuclein
  • Scientific Description
    Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimers disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2016]
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • In Vitro Generation of Brain Regulatory T Cells by Co-culturing With Astrocytes.
    Read more
  • Structural brain changes in Ser129-phosphorylated alpha-synuclein rats based on voxel-based morphometry. Wang J et al., 2020 Sep 1, Behav Brain Res
    Read more
  • LY354740 Reduces Extracellular Glutamate Concentration, Inhibits Phosphorylation of Fyn/NMDARs, and Expression of PLK2/pS129 alpha-Synuclein in Mice Treated With Acute or Sub-Acute MPTP. Tan Y et al., 2020, Front Pharmacol
    Read more
  • Exosomes from patients with Parkinsons disease are pathological in mice. Han C et al., 2019 Sep, J Mol Med (Berl)
    Read more
  • Palpha-syn* mitotoxicity is linked to MAPK activation and involves tau phosphorylation and aggregation at the mitochondria. Grassi D et al., 2019 Apr, Neurobiol Dis
    Read more

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