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ICC/IF analysis of formalin-fixed HEK293T cells using GTX54991 alpha Synuclein (phospho Ser129) antibody. Red : Primary antibody Blue : DAPI Permeabilization : 0.1% Triton X-100 in TBS for 5-10 minutes

alpha Synuclein (phospho Ser129) antibody

GTX54991

ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin

Product group Antibodies

ReactivityHuman, Mouse, Rat

TargetSNCA

Overview

Supplier
GeneTex
Product Name
alpha Synuclein (phospho Ser129) antibody
Delivery Days Customer
9
Application Supplier Note
WB: 1:500 - 1:1000. ICC/IF: 1:100 - 1:500. IHC-P: 1:100 - 1:200. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Applications
ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin
Certification
Research Use Only
Clonality
Polyclonal
Conjugate
Unconjugated
Gene ID6622
Target name
SNCA
Target description
synuclein alpha
Target synonyms
NACP, PARK1, PARK4, PD1, alpha-synuclein, I+/--synuclein, non A-beta component of AD amyloid, synuclein alpha-140, synuclein, alpha (non A4 component of amyloid precursor)
Host
Rabbit
Isotype
IgG
Protein IDP37840
Protein Name
Alpha-synuclein
Scientific Description
Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimers disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2016]
Reactivity
Human, Mouse, Rat
Storage Instruction
-20°C or -80°C,2°C to 8°C
UNSPSC
12352203

References

Yamamoto S, Matsui A, Ohyagi M, et al. In Vitro Generation of Brain Regulatory T Cells by Co-culturing With Astrocytes. Front Immunol. 2022,13:960036. doi: 10.3389/fimmu.2022.960036
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Wang J, Tan Y, Peng Q, et al. Structural brain changes in Ser129-phosphorylated alpha-synuclein rats based on voxel-based morphometry. Behav Brain Res. 2020,393:112786. doi: 10.1016/j.bbr.2020.112786
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Tan Y, Xu Y, Cheng C, et al. LY354740 Reduces Extracellular Glutamate Concentration, Inhibits Phosphorylation of Fyn/NMDARs, and Expression of PLK2/pS129 α-Synuclein in Mice Treated With Acute or Sub-Acute MPTP. Front Pharmacol. 2020,11:183. doi: 10.3389/fphar.2020.00183
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Han C, Xiong N, Guo X, et al. Exosomes from patients with Parkinson's disease are pathological in mice. J Mol Med (Berl). 2019,97(9):1329-1344. doi: 10.1007/s00109-019-01810-z
Read this paper
Grassi D, Diaz-Perez N, Volpicelli-Daley LA, et al. Pα-syn* mitotoxicity is linked to MAPK activation and involves tau phosphorylation and aggregation at the mitochondria. Neurobiol Dis. 2019,124:248-262. doi: 10.1016/j.nbd.2018.11.015
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alpha Synuclein (phospho Ser129) antibody

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