Alrizomadlin

MedChem Express

Alrizomadlin [1818393-16-6]

10

1818393-16-6

Research Use Only

98.67

C34H38Cl2FN3O4

642.59

Alrizomadlin (APG-115) is an orally active MDM2 protein inhibitor binding to MDM2 protein with IC 50 and K i values of 3.8 nM and 1 nM, respectively [1] . Alrizomadlin blocks the interaction of MDM2 and p53 and induces cell-cycle arrest and apoptosis in a p53-dependent manner [2] [3] .

O=C(N1)[C@]([C@@H](C(C=CC=C2Cl)=C2F)[C@@H]3C(NC45CCC(C(O)=O)(CC5)CC4)=O)(C(C1=C6)=CC=C6Cl)C7(CCCCC7)N3CC

-20°C,2°C to 8°C

12352200