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Alrizomadlin [1818393-16-6]

Alrizomadlin [1818393-16-6]

T14303
TargetMol Chemicals
CAS Number1818393-16-6
DownloadMSDS
Product group Chemicals
Estimated Purity98.79%
Molecular Weight642.59
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Overview

  • Supplier
    TargetMol Chemicals
  • Product Name
    Alrizomadlin [1818393-16-6]
  • Delivery Days Customer
    9
  • CAS Number
    1818393-16-6
  • Category Supplier
    Chemical
  • Certification
    Research Use Only
  • Chemical Name
    Alrizomadlin
  • Estimated Purity
    98.79%
  • Molecular Formula
    C34H38Cl2FN3O4
  • Molecular Weight
    642.59
  • Scientific Description
    Alrizomadlin is an orally active MDM2 inhibitor. APG-115 shows significant dose-dependent inhibitory effects on TP53wt AML cell lines. The IC50 values are 26.8 nM for MOLM-13 cells and 165.9 nM for MV-4-11 cells. , OCI-AML-3 cells 315.6 nM. Alrizomadlin blocks the interaction of MDM2 and p53 and induces cell cycle arrest and apoptosis in a p53-dependent manner.
  • Shelf life instruction
    3 years
  • SMILES
    CCN1[C@H]([C@H](c2cccc(Cl)c2F)[C@]2(C(=O)Nc3cc(Cl)ccc23)C11CCCCC1)C(=O)NC12CCC(CC1)(CC2)C(O)=O
  • Storage Instruction
    -20°C
  • UNSPSC
    12352200

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