ALS2 antibody, C-term

GeneTex

ALS2 antibody, C-term

7

IHC-P: 3-5microg/ml. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

Polyclonal

0.50 mg/ml

Unconjugated

ALS2

alsin Rho guanine nucleotide exchange factor ALS2

ALS2CR6, ALSJ, IAHSP, PLSJ, alsin, ALS2, alsin Rho guanine nucleotide exchange factor, amyotrophic lateral sclerosis 2 (juvenile), amyotrophic lateral sclerosis 2 chromosomal region candidate gene 6 protein, amyotrophic lateral sclerosis 2 protein

Goat

IgG

Alsin

The protein encoded by this gene contains an ATS1/RCC1-like domain, a RhoGEF domain, and a vacuolar protein sorting 9 (VPS9) domain, all of which are guanine-nucleotide exchange factors that activate members of the Ras superfamily of GTPases. The protein functions as a guanine nucleotide exchange factor for the small GTPase RAB5. The protein localizes with RAB5 on early endosomal compartments, and functions as a modulator for endosomal dynamics. Mutations in this gene result in several forms of juvenile lateral sclerosis and infantile-onset ascending spastic paralysis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]

-20°C or -80°C,2°C to 8°C

12352203