Alsterpaullone

MedChem Express

Alsterpaullone [237430-03-4]

5

237430-03-4

Research Use Only

99.85

C16H11N3O3

293.28

Alsterpaullone (9-Nitropaullone) is a potent CDK inhibitor, with IC 50 s of 35 nM, 15 nM, 200 nM and 40 nM for CDK1/cyclin B , CDK2/cyclin A , CDK2/cyclin E and CDK5/p35 , respectively. Alsterpaullone also competes with ATP for binding to GSK-3alpha/GSK-3beta with IC 50 s of both 4 nM. Alsterpaullone has antitumor activity, and possesses potential for the study in neurodegenerative and proliferative disorders [1] . Alsterpaullone induces apoptosis in leukemia cell line [2] .

O=C1NC2=CC=CC=C2C(NC3=C4C=C([N+]([O-])=O)C=C3)=C4C1

-20°C,2°C to 8°C

12352200