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Aminoacylase 1 antibody [N2C3-2]

GTX110348
GeneTex
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman
TargetACY1
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Overview

  • Supplier
    GeneTex
  • Product Name
    Aminoacylase 1 antibody [N2C3-2]
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    1 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID95
  • Target name
    ACY1
  • Target description
    aminoacylase 1
  • Target synonyms
    ACY-1; ACY1D; acylase; aminoacylase-1; epididymis secretory protein Li 5; HEL-S-5; N-acyl-L-amino-acid amidohydrolase
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDQ03154
  • Protein Name
    Aminoacylase-1
  • Scientific Description
    Aminoacylase-1 is a cytosolic, homodimeric, zinc-binding enzyme that catalyzes the hydrolysis of acylated L-amino acids to L-amino acids and acyl group, and has been postulated to function in the catabolism and salvage of acylated amino acids. ACY1 has been assigned to chromosome 3p21.1, a region reduced to homozygosity in small-cell lung cancer (SCLC), and its expression has been reported to be reduced or undetectable in SCLC cell lines and tumors. The amino acid sequence of human aminoacylase-1 is highly homologous to the porcine counterpart, and ACY1 is the first member of a new family of zinc-binding enzymes. [provided by RefSeq]
  • Reactivity
    Human
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Expanding the phenotype in aminoacylase 1 (ACY1) deficiency: characterization of the molecular defect in a 63-year-old woman with generalized dystonia. Sass JO et al., 2016 Jun, Metab Brain Dis
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  • The molecular basis of aminoacylase 1 deficiency. Sommer A et al., 2011 Jun, Biochim Biophys Acta
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