ProductsBack/AMPK alpha 1 (phospho Thr183) + AMPK alpha 2 (phospho Thr172) antibody

AMPK alpha 1 (phospho Thr183) + AMPK alpha 2 (phospho Thr172) antibody

Name: AMPK alpha 1 (phospho Thr183) + AMPK alpha 2 (phospho Thr172) antibody
SKU: GTX130429_G10
Availability: BackOrder

GTX130429

ApplicationsWestern Blot

Product group Antibodies

ReactivityHuman, Mouse

TargetPRKAA1

Overview

Supplier
GeneTex
Product Name
AMPK alpha 1 (phospho Thr183) + AMPK alpha 2 (phospho Thr172) antibody
Delivery Days Customer
9
Application Supplier Note
WB: 1:500-1:3000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Applications
Western Blot
Certification
Research Use Only
Clonality
Polyclonal
Concentration
1.5 mg/ml
Conjugate
Unconjugated
Gene ID5562
Target name
PRKAA1
Target description
protein kinase AMP-activated catalytic subunit alpha 1
Target synonyms
AMPK, AMPK alpha 1, AMPKa1, 5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase, catalytic alpha-1 chain, ACACA kinase, AMP -activate kinase alpha 1 subunit, AMP-activated protein kinase, catalytic, alpha-1, AMPK subunit alpha-1, AMPK, alpha, 1, HMGCR kinase, acetyl-CoA carboxylase kinase, hydroxymethylglutaryl-CoA reductase kinase, protein kinase, AMP-activated, alpha 1 catalytic subunit, tau-protein kinase PRKAA1
Host
Rabbit
Isotype
IgG
Protein IDQ13131
Protein Name
5'-AMP-activated protein kinase catalytic subunit alpha-1
Scientific Description
The protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq]
Reactivity
Human, Mouse
Storage Instruction
-20°C or -80°C,2°C to 8°C
UNSPSC
12352203

References

Suzuki K, Kubota Y, Kaneko K, et al. CLPX regulates mitochondrial fatty acid β-oxidation in liver cells. J Biol Chem. 2023,299(10):105210. doi: 10.1016/j.jbc.2023.105210
Read this paper
Su WP, Li CJ, Lin LT, et al. Boosting mitochondrial function and metabolism in aging female germ cells with dual ROCK/ROS inhibition. Biomed Pharmacother. 2023,163:114888. doi: 10.1016/j.biopha.2023.114888
Read this paper
Lee S, Jo M, Lee HE, et al. HEXA-018, a Novel Inducer of Autophagy, Rescues TDP-43 Toxicity in Neuronal Cells. Front Pharmacol. 2021,12:747975. doi: 10.3389/fphar.2021.747975
Read this paper
Jiang WP, Deng JS, Huang SS, et al. Sanghuangporus sanghuang Mycelium Prevents Paracetamol-Induced Hepatotoxicity through Regulating the MAPK/NF-κB, Keap1/Nrf2/HO-1, TLR4/PI3K/Akt, and CaMKKβ/LKB1/AMPK Pathways and Suppressing Oxidative Stress and Inflammation. Antioxidants (Basel). 2021,10(6). doi: 10.3390/antiox10060897
Read this paper
Houshmand F, Barati M, Golab F, et al. Metformin-induced AMPK activation stimulates remyelination through induction of neurotrophic factors, downregulation of NogoA and recruitment of Olig2+ precursor cells in the cuprizone murine model of multiple sclerosis. Daru. 2019,27(2):583-592. doi: 10.1007/s40199-019-00286-z
Read this paper
Irungbam K, Churin Y, Matono T, et al. Cannabinoid receptor 1 knockout alleviates hepatic steatosis by downregulating perilipin 2. Lab Invest. 2020,100(3):454-465. doi: 10.1038/s41374-019-0327-5
Read this paper
Lin YN, Chang HY, Wang CCN, et al. Oleanolic Acid Inhibits Liver X Receptor Alpha and Pregnane X Receptor to Attenuate Ligand-Induced Lipogenesis. J Agric Food Chem. 2018,66(42):10964-10976. doi: 10.1021/acs.jafc.8b03372
Read this paper