Amsilarotene

MedChem Express

Amsilarotene [125973-56-0]

10

125973-56-0

Research Use Only

99.67

C20H27NO3Si2

385.60

Amsilarotene (TAC-101; Am 555S), an orally active synthetic retinoid, has selective affinity for retinoic acid receptor alpha ( RAR-alpha ) binding with K i of 2.4, 400 nM for RAR-alpha and RAR-beta. Amsilarotene induces the apoptotic of human gastric cancer, hepatocellular carcinoma and ovarian carcinoma cells. Amsilarotene can be used for the research of cancer [1] [2] [3] .

C[Si](C)(C)C1=CC(C(NC2=CC=C(C(O)=O)C=C2)=O)=CC([Si](C)(C)C)=C1

-20°C,2°C to 8°C

12352200