Androgen Receptor antibody [3C6-F12-F11]

GeneTex

Androgen Receptor antibody [3C6-F12-F11]

9

The Mouse anti-human AR antibody specifically detects targets derived from human recombinant protein at various concentrations. Cross reactivity with mouse and rat are expected from sequence similarity.

Recommended Starting Dilutions: For ELISA: Use at a concentration of 12.5 ng/ml. For WB: Use at a dilution of 1:2,000. Optimal working dilutions should be determined experimentally be the end user.

Western Blot, ELISA

Research Use Only

Monoclonal

3C6-F12-F11

1 mg/ml

Unconjugated

AR

androgen receptor

AIS; androgen receptor; AR8; DHTR; dihydrotestosterone receptor; HUMARA; HYSP1; KD; NR3C4; nuclear receptor subfamily 3 group C member 4; SBMA; SMAX1; TFM

Mouse

IgG1

Androgen receptor

The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract from the normal 9-34 repeats to the pathogenic 38-62 repeats causes spinal bulbar muscular atrophy (SBMA, also known as Kennedys disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2017]

Human

-20°C or -80°C,2°C to 8°C

12352203