Androgen Receptor antibody, N-term

GeneTex

Androgen Receptor antibody, N-term

7

This antibody is expected to recognize isoform 1 (NP_000035.2) only.

WB: 0.1-0.5microg/ml. ICC/IF: 10microg/ml. IHC-P: 2-3microg/ml. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Research Use Only

Polyclonal

0.50 mg/ml

Unconjugated

Liquid

AR

androgen receptor

AIS; androgen receptor; AR8; DHTR; dihydrotestosterone receptor; HUMARA; HYSP1; KD; NR3C4; nuclear receptor subfamily 3 group C member 4; SBMA; SMAX1; TFM

Goat

IgG

Androgen receptor

The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract from the normal 9-34 repeats to the pathogenic 38-62 repeats causes spinal bulbar muscular atrophy (SBMA, also known as Kennedys disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2017]

-20°C or -80°C,2°C to 8°C

12352203