Anti-5T4 [m1002]

Absolute Antibody

Anti-5T4 [m1002]

9

This antibody binds 5T4 antigen expressed on carcinomas.

5T4 is an oncofetal antigen expressed in a number of carcinomas including colorectal, ovarian, renal, non-small cell lung and gastric carcinomas, while its expression in normal adult tissues is limited. This antibody is recomended for diagnosis of cancer in a patient. Fab version of this antibody bound to 5T4 with an EC50 of 2 nmol/L, as measured by ELISA. This antibody was also capable of binding native 5T4 associated with cell surfaces. The binding of m1001 to surface expressed 5T4 on A498 cells was confirmed using flow cytometry (WO2016022939).

Flow Cytometry, ELISA

Research Use Only

Monoclonal

m1002

TPBG

trophoblast glycoprotein

5T4; 5T4 oncofetal antigen; 5T4 oncofetal trophoblast glycoprotein; 5T4 oncotrophoblast glycoprotein; 5T4AG; M6P1; trophoblast glycoprotein; WAIF1; wnt-activated inhibitory factor 1

Rabbit

IgG

Trophoblast glycoprotein

This chimeric rabbit antibody was made using the variable domain sequences of the original Human IgG1 format, for improved compatibility with existing reagents, assays and techniques.

Human

-20°C,2°C to 8°C

12352203