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Anti-ACE2 [h11B11]

AB03703-1.1
Absolute Antibody
ApplicationsFlow Cytometry, ELISA, Neutralisation/Blocking
Product group Antibodies
TargetACE2
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Overview

  • Supplier
    Absolute Antibody
  • Product Name
    Anti-ACE2 [h11B11]
  • Delivery Days Customer
    9
  • Application Supplier Note
    This antibody can bind purified human ACE2 recombinant protein in an ELISA. The ability of this antibody to bind ACE2 and block its interaction with SARS-CoV-RBD and SARS-CoV-2-RBD was determined using flow cytometry. The binding affinity of the IgG1 version of this antibody to wild type human ACE2 was found to be Kd= 1.95 nM. This antibody was also capable of binding mutated versions of human ACE2 like I21T, K26R, N33D and D38E. This antibody does not inhibit the carboxypeptidase activity of hACE2 in vitro. This antibody showed strong inhibitory activity against SARS-CoV, SARS-CoV-2, and epidemic SARS-CoV-2 variant pseudo virus in vitro. When administered therapeutically or prophylactically in the hACE2 mouse model, this antibody alleviates and prevents SARS-CoV-2 replication and virus-induced pathological syndromes. This antibody also didnt exhibit any significant toxicity to cynomolgus monkey when administered in high doses (PMID: 34404805).
  • Applications
    Flow Cytometry, ELISA, Neutralisation/Blocking
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    h11B11
  • Gene ID59272
  • Target name
    ACE2
  • Target description
    angiotensin converting enzyme 2
  • Target synonyms
    ACEH; ACE-related carboxypeptidase; angiotensin I converting enzyme (peptidyl-dipeptidase A) 2; angiotensin I converting enzyme 2; angiotensin-converting enzyme 2; angiotensin-converting enzyme homolog; angiotensin-converting enzyme-related carboxypeptidase; metalloprotease MPROT15; peptidyl-dipeptidase A; truncated angiotensin converting enzyme 2
  • Host
    Mouse
  • Isotype
    IgG1
  • Protein IDQ9BYF1
  • Protein Name
    Angiotensin-converting enzyme 2
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352203

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