anti-ACE2 (human), mAb (AC18F)

AdipoGen Life Sciences

anti-ACE2 (human), mAb (AC18F)

10

Recognizes human ACE2. Does not detect recombinant human ACE2 that has a tag at the C-terminus of the protein.

Flow Cytometry, Western Blot, ELISA

Research Use Only

Monoclonal

AC18F

1 mg/ml

Liquid

ACE2

angiotensin converting enzyme 2

ACEH; ACE-related carboxypeptidase; angiotensin I converting enzyme (peptidyl-dipeptidase A) 2; angiotensin I converting enzyme 2; angiotensin-converting enzyme 2; angiotensin-converting enzyme homolog; angiotensin-converting enzyme-related carboxypeptidase; metalloprotease MPROT15; peptidyl-dipeptidase A; truncated angiotensin converting enzyme 2

Mouse

IgG1

Angiotensin-converting enzyme 2

Angiotensin-converting enzyme2 (ACE2) is an ectoenzyme (carboxypeptidase) with an extracellular catalytic domain that predominantly localizes at the plasma membrane and is thereby able to hydrolyze circulating peptides. ACE2 has approximately 42% sequence identity with ACE, and its cytoplasmic and transmembrane domains show 48% homology to the protein collectrin that plays a critical role in the amino acid absorption of the kidney. ACE2 converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. ACE2 is involved in the regulation of systemic blood pressure and has direct effects on cardiac functions. It is expressed predominantly in endothelial cells of the lung, gut, heart and kidney. ACE2 together with the protease TMPRSS2 acts as a functional receptor for SARS coronavirus as well as for the new highly pathogenic coronavirus, 2019-nCoV/SARS-CoV-2, which is cause for pneumonia COVID-19. - Monoclonal Antibody. Recognizes human ACE2. Isotype: Mouse IgG1kappa. Clone: AC18F. Applications: ELISA, FACS, WB. Liquid. 0.2microm-filtered solution in PBS, pH 7.4. Contains no preservatives. ACE2 has direct effects on cardiac functions. It is expressed predominantly in vascular endothelial cells of the heart and kidney. ACE2 converts angiotensin I to angiotensin 1-9. ACE2 was also identified as a functional receptor for SARS coronavirus.

Human

-20°C,2°C to 8°C

12352203