Anti-Acetylcholinesterase [10D]

Absolute Antibody

Anti-Acetylcholinesterase [10D]

9

This antibody binds human acetylcholinesterase, which is a cholinergic enzyme primarily found at postsynaptic neuromuscular junctions, especially in muscles and nerves. It immediately breaks down or hydrolyzes acetylcholine (ACh), a naturally occurring ne

Acetylcholinesterase is an enzyme that catalyzes the breakdown of acetylcholine and of some other choline esters that function as neurotransmitters. The original mouse IgG1 version of this antibody binds human acetylcholinesterase with a binding affinity of 0.4 nM. The binding affinity of mouse IgG1 version for truncated, monomeric recombinant HuAChE was measured by ELISA. This antibody was used in the immunopurification of membrane bound AChE on human RBCs by binding on immobilized antibody for further detection by mass spectrometry. RBC AChE can be used as a biomarker for exposure to organophosphorus pesticides and nerve agents (PMID: 28892361).

ELISA

Research Use Only

Monoclonal

10D

ACHE

acetylcholinesterase (Cartwright blood group)

ACEE; acetylcholinesterase; acetylcholinesterase (Yt blood group); apoptosis-related acetylcholinesterase; ARACHE; N-ACHE; YT; Yt blood group

Rabbit

IgG

Acetylcholinesterase

This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG1 format for improved compatibility with existing reagents assays and techniques.

Human

-20°C,2°C to 8°C

12352203