Anti-AKR7A2 Antibody

HUABIO

Anti-AKR7A2 Antibody

7

ImmunoFluorescence, Western Blot

WB,IF-Cell

Research Use Only

Polyclonal

1 mg/ml

Unconjugated

AKR7A2

aldo-keto reductase family 7 member A2

AFAR, AFAR1, AFB1-AR1, AKR7, aflatoxin B1 aldehyde reductase member 2, AFB1 aldehyde reductase 1, AFB1-AR 1, HEL-S-166mP, SSA reductase, aflatoxin aldehyde reductase, aflatoxin beta1 aldehyde reductase, aldoketoreductase 7, epididymis secretory sperm binding protein Li 166mP, succinic semialdehyde reductase

Rabbit

IgG

Aflatoxin B1 aldehyde reductase member 2

Catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate. May have an important role in producing the neuromodulator gamma-hydroxybutyrate (GHB). Has broad substrate specificity. Has NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2-nitrobenzaldehyde and pyridine-2-aldehyde (in vitro). Can reduce 1,2-naphthoquinone and 9,10-phenanthrenequinone (in vitro). Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen. The protein encoded by this gene belongs to the aldo/keto reductase (AKR) superfamily and AKR7 family, which are involved in the detoxification of aldehydes and ketones. The AKR7 family consists of 3 genes that are present in a cluster on the p arm of chromosome 1. This protein, thought to be localized in the golgi, catalyzes the NADPH-dependent reduction of succinic semialdehyde to the endogenous neuromodulator, gamma-hydroxybutyrate. It may also function as a detoxication enzyme in the reduction of aflatoxin B1 and 2-carboxybenzaldehyde. Alternative splicing results in multiple transcript variants.

Human, Mouse, Rat

Human,Mouse,Rat

-20°C,2°C to 8°C

41116161