anti-AMPK alpha-1 (human), Rabbit Monoclonal (RM301)

RevMAb Biosciences

anti-AMPK alpha-1 (human), Rabbit Monoclonal (RM301)

5

Western Blot, ImmunoHistoChemistry

Research Use Only

Monoclonal

RM301

PRKAA1

protein kinase AMP-activated catalytic subunit alpha 1

5'-AMP-activated protein kinase catalytic subunit alpha-1; 5'-AMP-activated protein kinase, catalytic alpha-1 chain; ACACA kinase; acetyl-CoA carboxylase kinase; AMP -activate kinase alpha 1 subunit; AMP-activated protein kinase, catalytic, alpha-1; AMPK; AMPK alpha 1; AMPK subunit alpha-1; AMPK, alpha, 1; AMPKa1; HMGCR kinase; hydroxymethylglutaryl-CoA reductase kinase; protein kinase, AMP-activated, alpha 1 catalytic subunit; tau-protein kinase PRKAA1

Rabbit

IgG

AMP-activated protein kinase (AMPK) is a heterotrimeric complex consisting of a catalytic alpha subunit and regulatory beta and gamma subunits. Each subunit exists as alternate isoforms ( alpha 1, alpha 2, beta 1, beta 2, gamma 1, gamma 2, gamma 3), with all 12 combinations able to form complexes. The catalytic alpha subunit of AMPK is activated allosterically by AMP, and by phosphorylation via the AMPK kinases LKB1 and CaMKK beta. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. AMPKs role in metabolic regulation has implicated this serine/threonine kinase as a therapeutic target in heart disease, obesity and diabetes. 5-AMP-activated protein kinase catalytic subunit alpha-1 (AMPK alpha 1) belongs to the serine/threonine protein kinase family and is the catalytic subunit of the 5-prime-AMP-activated protein kinase (AMPK). - Recombinant Antibody. This antibody reacts to human AMPK alpha-1 (AMPKA1) (5-AMP-activated protein kinase catalytic subunit alpha-1). Applications: WB, IHC. Source: Rabbit. Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide. AMP-activated protein kinase (AMPK) is a heterotrimeric complex consisting of a catalytic alpha subunit and regulatory beta and gamma subunits. Each subunit exists as alternate isoforms ( alpha 1, alpha 2, beta 1, beta 2, gamma 1, gamma 2, gamma 3), with all 12 combinations able to form complexes. The catalytic alpha subunit of AMPK is activated allosterically by AMP, and by phosphorylation via the AMPK kinases LKB1 and CaMKK beta. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. AMPKs role in metabolic regulation has implicated this serine/threonine kinase as a therapeutic target in heart disease, obesity and diabetes. 5-AMP-activated protein kinase catalytic subunit alpha-1 (AMPK alpha 1) belongs to the serine/threonine protein kinase family and is the catalytic subunit of the 5-prime-AMP-activated protein kinase (AMPK).

Human

-20°C

12352203