Anti-Amyloid Beta [21F12]

Absolute Antibody

Anti-Amyloid Beta [21F12]

7

This antibody recognizes amino acids 33-42 of amyloid beta.

This antibody has very high specificity for Abeta1-42 over Abeta1-40. This antibody is capable of immunoprecipitating Abeta peptides ending at aa position 42 and also p3 peptides (PMID: 8917563). This antibody is also recomended for detection of amyloid beta using sandwich ELISA (PMID: 9037091, 19204155). This antibody was also used in the quantification of the proportion of full-length Abeta using western blotting (PMID: 12787077). This antibody has also been used for the identification of Abeta42 plaques on paraffin frontal sections(PMID: 15215183, 19660650). This antibody is unable to bind plaques in unfixed brain sections. This antibody is also not capable of clearing plaque after in vivo administration (PMID: 10932230).

ImmunoPrecipitation, Western Blot, ELISA, ImmunoHistoChemistry

IP; ELISA; WB; IHC

Research Use Only

Monoclonal

21F12

APP

amyloid beta precursor protein

AAA; ABETA; ABPP; AD1; alpha-sAPP; alzheimer disease amyloid protein; amyloid beta (A4) precursor protein; amyloid beta A4 protein; amyloid precursor protein; amyloid-beta precursor protein; APPI; beta-amyloid peptide; beta-amyloid peptide(1-40); beta-amyloid peptide(1-42); beta-amyloid precursor protein; cerebral vascular amyloid peptide; CTFgamma; CVAP; peptidase nexin-II; PN2; PN-II; preA4; protease nexin-II; testicular tissue protein Li 2

Human

IgG1

Amyloid-beta A4 protein

This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG2b format, for improved compatibility with existing reagents, assays and techniques.

Human

Human

The original antibody was generated by immunizing A/J mice with a synthetic peptide (NH2-CYS-NH-CH2-(CH2)5-CO-GLMVGGVVIA-COOH) as an immunogen.

-20°C,2°C to 8°C

12352203