Anti-Axl Antibody

HUABIO

Anti-Axl Antibody

7

Flow Cytometry, ImmunoFluorescence, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

WB,IF-Cell

Research Use Only

Polyclonal

1 mg/ml

Unconjugated

AXL

AXL receptor tyrosine kinase

ARK, AXL3, JTK11, Tyro7, UFO, tyrosine-protein kinase receptor UFO, AXL oncogene, AXL transforming sequence/gene

Rabbit

IgG

Tyrosine-protein kinase receptor UFO

The AXL receptor transduces signals from the extracellular matrix into the cytoplasm by binding growth factors like vitamin K-dependent protein growth-arrest-specific gene 6 (GAS6). It is involved in the stimulation of cell proliferation and survival. Proteolytic cleavage of the AXL extracellular domain by the metalloproteinases ADAM10 and ADAM17 can downregulate this signalling activity. Signalling pathways activated downstream of AXL include PI3K-AKT-mTOR, MEKERK, NF-kappaB, and JAK/STAT. This receptor can also mediate cell aggregation by homophilic binding. AXL protein is expressed in normal tissues, particularly in bone marrow stroma and myeloid cells, and in tumour cells and tumour vasculature. In cancer, AXL is expressed on the tumor cells as well as adjacent immune cells including dendritic cells, macrophages, and NK cells. Axl is an inhibitor of the innate immune response. The function of activated AXL in normal tissues includes the efficient clearance of apoptotic material and the dampening of TLR-dependent inflammatory responses and natural killer cell activity. AXL is a putative driver of diverse cellular processes that are critical for the development, growth, and spread of tumours, including proliferation, invasiveness and migration, epithelial-to-mesenchymal transition, stemness, angiogenesis, and immune modulation. AXL has been implicated as a cancer driver and correlated with poor survival in numerous aggressive tumors including triple-negative breast cancer (TNBC), acute myeloid leukemia (AML), non-small-cell lung cancer (NSCLC), pancreatic cancer and ovarian cancer, among others.

Human, Mouse

Human,Mouse

-20°C,2°C to 8°C

41116161