Anti-BACE2 [1/ 9 ]

Absolute Antibody

Anti-BACE2 [1/ 9 ]

9

The antibody binds specifically to BACE2, an enzyme responsible for the proteolytic cleavage of amyloid precursor protein (APP). The protein is cleaved between residues 690 and 691, leading to the formation of beta-cleaved soluble APP and a C-terminal membrane bound fragment (CTFbeta). The latter is then cleaved by gamma-secretase to generate amyloid beta peptide. BACE is the rate-limiting enzyme in the pathway, and is a potential target in the treatment of Alzheimers Disease (AD),a neurodegenerative disorder characterised by amyloid beta plaques within the brain. The BACE2 protein is encoded in chromosome 21, in a region critical for the development of Downs Syndrome, and may play a role in the amyloid beta deposition in the disease.

Western Blot, ImmunoHistoChemistry

Research Use Only

Monoclonal

1/ 9

BACE2

beta-secretase 2

56 kDa aspartic-like protease; AEPLC; ALP56; ASP1; ASP21; aspartyl protease 1; BAE2; beta-secretase 2; beta-site amyloid beta A4 precursor protein-cleaving enzyme 2; beta-site APP-cleaving enzyme 2; CDA13; CEAP1; Down syndrome region aspartic protease; DRAP; memapsin-1; membrane-associated aspartic protease 1; SLCO3A1/BACE2 fusion; theta-secretase; transmembrane aspartic proteinase Asp1

Human

Beta-secretase 2

This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG format, for improved compatibility with existing reagents, assays and techniques.

Human

-20°C,2°C to 8°C

12352203