Anti-Beta Dystroglycan [AS30SS_Hu6]

Absolute Antibody

Anti-Beta Dystroglycan [AS30SS_Hu6]

7

The binding specificity of this antibody for human and mouse beta dystroglycan (beta-DG) was confirmed using ELISA. This antibody is capable of immunoprecipitating both alpha-DG and beta-DG from C2C12 cell lysates, suggesting that the binding epitope of this antibody on beta dystroglycan is different from that of alpha dystroglycan. This antibody can also be used for the identification human beta-DG, mouse beta-DG and recombinant beta dystroglycan in a western blot. This antibody was also used for the immunofluorescent staining of unfixed human and mouse muscle tissues. This antibody was used in combination with anti-laminin-2 antibody C3_Hu10 to generate a duobody called TBTI (US11254737).

ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ELISA

ELISA; IP; WB; IF

Research Use Only

Monoclonal

AS30SS_Hu6

DAG1

dystroglycan 1

156DAG; A3a; AGRNR; DAG; dystroglycan; dystroglycan 1 (dystrophin-associated glycoprotein 1); LGMDR16; MDDGA9; MDDGC7; MDDGC9

Rabbit

IgG

Dystroglycan

This chimeric rabbit antibody was made using the variable domain sequences of the original Human IgG1 format for improved compatibility with existing reagents assays and techniques.

Human, mouse

The original antibody was generated by immunizing Balb/c and Trianni mice with human beta-dystroglycan. Humanized version was generated by grafting CDRs of parental mouse antibody AS30 onto human framework regions.

-20°C,2°C to 8°C

12352203