Anti-BOB1 Antibody

HUABIO

Anti-BOB1 Antibody

7

Flow Cytometry, Western Blot

WB,FC

Research Use Only

Polyclonal

1 mg/ml

Unconjugated

POU2AF1

POU class 2 homeobox associating factor 1

BOB1, OBF-1, OBF1, OCAB, POU domain class 2-associating factor 1, B-cell-specific coactivator OBF-1, BOB-1, OCA-B, OCT-binding factor 1, POU class 2 associating factor 1

Rabbit

IgG

POU domain class 2-associating factor 1

Transcriptional coactivator that specifically associates with either OCT1 or OCT2. It boosts the OCT1 mediated promoter activity and to a lesser extent, that of OCT2. It has no intrinsic DNA-binding activity. It recognizes the POU domains of OCT1 and OCT2. It is essential for the response of B-cells to antigens and required for the formation of germinal centers. Reduced activation of Bob1-deficient B cells following antigenic stimulation is often reported. The action of Bob1 on B cell maturation and tolerance could be mediated by effects on B cell activation, in part by regulating the expression of immunosuppressive miRNAs. Bob1 has long been considered a B cell-specific factor that interacts with the transcription factors Oct1 and Oct2 to enhance octamer-dependent transcription. Bob1 can directly bind to and transactivate the promoters of Bcl6 and Btla.

Human, Mouse, Rat

Human,Mouse,Rat

-20°C,2°C to 8°C

41116161