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Immunohistochemical staining of formalin fixed and paraffin embedded melanoma tissue sections.
Immunohistochemical staining of formalin fixed and paraffin embedded melanoma tissue sections.
Immunohistochemical staining of formalin fixed and paraffin embedded melanoma tissue sections.

anti-BRAF (V600E) (human), Rabbit Monoclonal (RM8)

Research Use Only
REV-31-1042-00
RevMAb Biosciences
ApplicationsImmunoCytoChemistry, ImmunoHistoChemistry, Western Blot
Product group Antibodies
ReactivityHuman
TargetBRAF
Price on request
Packing Size
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Overview

  • Supplier
    RevMAb Biosciences
  • Product Name
    anti-BRAF (V600E) (human), Rabbit Monoclonal (RM8)
  • Delivery Days Customer
    5
  • Applications
    ImmunoCytoChemistry, ImmunoHistoChemistry, Western Blot
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    RM8
  • Concentration
    1 mg/ml
  • Gene ID673
  • Target name
    BRAF
  • Target description
    B-Raf proto-oncogene, serine/threonine kinase
  • Target synonyms
    94 kDa B-raf protein; B-raf; B-Raf proto-oncogene serine/threonine-protein kinase (p94); B-Raf serine/threonine-protein; BRAF1; B-RAF1; murine sarcoma viral (v-raf) oncogene homolog B1; NS7; proto-oncogene B-Raf; RAFB1; serine/threonine-protein kinase B-raf; v-raf murine sarcoma viral oncogene homolog B; v-raf murine sarcoma viral oncogene homolog B1
  • Host
    Rabbit
  • Isotype
    IgG
  • Scientific Description
    BRAF is a human gene that encodes a protein called B-Raf. B-Raf is a member of the Raf kinase family of growth signal transduction protein kinases. This protein plays a role in regulating the MAP kinase/ERKs signaling pathway, which affects cell division, differentiation and secretion. Mutations in the BRAF gene can cause birth defects (inherited) or cancer, as an oncogene. Mutations in this gene have been found in cancers, including non-Hodgkin lymphoma, colorectal cancer, malignant melanoma, papillary thyroid carcinoma, non-small-cell lung carcinoma, adenocarcinoma of the lung, brain tumors including glioblastoma and Pleomorphic Xanthoastrocytomas as well as inflammatory diseases like erdheim-chester disease. The majority (>90%) of BRAF mutant cancers harbor the V600E mutation. The mutation leads to activation of the MAPK signaling pathway that increases cell invasion and reduces apoptosis. It also leads to reduced expression of melanocyte differentiation antigens and subsequent immune evasion - Recombinant Antibody. This antibody reacts to the BRAF V600E mutant. No cross reactivity with wild type BRAF. Applications: WB, IHC, ICC. Source: Rabbit. Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide. BRAF is a human gene that encodes a protein called B-Raf. B-Raf is a member of the Raf kinase family of growth signal transduction protein kinases. This protein plays a role in regulating the MAP kinase/ERKs signaling pathway, which affects cell division, differentiation and secretion. Mutations in the BRAF gene can cause birth defects (inherited) or cancer, as an oncogene. Mutations in this gene have been found in cancers, including non-Hodgkin lymphoma, colorectal cancer, malignant melanoma, papillary thyroid carcinoma, non-small-cell lung carcinoma, adenocarcinoma of the lung, brain tumors including glioblastoma and Pleomorphic Xanthoastrocytomas as well as inflammatory diseases like erdheim-chester disease. The majority (>90%) of BRAF mutant cancers harbor the V600E mutation. The mutation leads to activation of the MAPK signaling pathway that increases cell invasion and reduces apoptosis. It also leads to reduced expression of melanocyte differentiation antigens and subsequent immune evasion
  • Reactivity
    Human
  • Storage Instruction
    -20°C
  • UNSPSC
    12352203